Alterations in energy production in a Drosophila model for the X-linked dystonia-parkinsonism-related Taf1 deficiency

BackgroundX-linked dystonia-parkinsonism (XDP), an adult-onset neurodegenerative disorder, is caused by an SVA insertion in the TAF1 gene, containing a hexanucleotide, the length of which is correlated to the severity of the disease. The SVA insertion moderately disrupts gene expression; however, th...

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Detalhes bibliográficos

Principais autores:	Frida Mandik, Shela Marie Algodon, Philip Seibler, Christine Klein, Melissa Vos
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-02-01
coleção:	Frontiers in Aging Neuroscience
Assuntos:	Drosophila melanogaster fatty acid oxidation intellectual disabilities (ID) TAF1 XDP
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnagi.2026.1684267/full
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