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Proliferation of activated hepatic stellate cells requires REST

Abstract Background Activation of hepatic stellate cells (HSCs) is key in liver regeneration and the pathogenesis of chronic liver diseases, such as metabolic dysfunction-associated steatohepatitis (MASH). Activated HSCs promote liver inflammation and fibrosis which can lead to the development of li...

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Autors principals: Vladimir S Shavva, L. Tarnawski, W. Dai, N. Moruzzi, A.-S. Haller, F. Borg, S. Hansson, Q. Guo, M. Cai, E. Fekete, J.J. Vacquié, A. Maestri, T. Liu, R.S. Vimaladithan, S.G. Malin, P. Saliba-Gustafsson, P.-O. Berggren, C.E. Hagberg, O. Ahmed, Peder S. Olofsson
Format: Artigo
Idioma:Inglês
Publicat: BMC 2026-01-01
Col·lecció:Molecular Medicine
Matèries:
Hepatic stellate cell activation
REST
Proliferation
Mitochondrial metabolism.
Accés en línia:https://doi.org/10.1186/s10020-025-01406-z
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