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Biomarker-Based Pharmacological Characterization of ENX-102, a Novel α2/3/5 Subtype-Selective GABAA Receptor Positive Allo-Steric Modulator: Translational Insights from Rodent and Human Studies

Gamma-aminobutyric acid type A receptors (GABA<sub>A</sub>Rs) are pentameric ligand-gated ion channels essential for inhibitory neurotransmission in the central nervous system. Subtype-specific expression patterns of GABA<sub>A</sub>R subunits underlie their diverse roles in regulating anxiety, moto...

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Principais autores: Pauline Nettesheim, Krishna C. Vadodaria, Kimberly E. Vanover, Laura G. J. M. Borghans, Estibaliz Arce, William Brubaker, Stephen Cunningham, Stephanie Parks, Jordi Serrats, Vikram Sudarsan, Eve Taylor, Erica Klaassen, Frederik E. Stuurman, Gabriel E. Jacobs
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-10-01
coleção:Cells
Assuntos:
GABA<sub>A</sub> receptor
benzodiazepine
subtype-selective
ENX-102
translational
Acesso em linha:https://www.mdpi.com/2073-4409/14/20/1575
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