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Metabolic engineering of Yarrowia lipolytica for enhanced microbial production of medium-chain α, ω-diols from alkanes via CRISPR-Cas9 mediated pathway optimization and P450 alkane monooxygenase overexpression

IntroductionMedium- to long-chain α, ω-diols are valuable building blocks for polyesters and polyurethanes, yet their microbial synthesis from inexpensive alkane feedstocks remains largely undeveloped. The oleaginous yeast Yarrowia lipolytica offers advantages over bacterial systems such as Escheric...

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Gespeichert in:
Hauptverfasser: Ye Chan Kim, Won Yoon Hwan Choi, Eun-Jung Kim, Byung‐Gee Kim, Hyungdon Yun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2025-10-01
Schriftenreihe:Frontiers in Bioengineering and Biotechnology
Schlagworte:
metabolic engineering
CRISPR-Cas9
diols
alkanes
hydroxylation
yarrowia lipolytica
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1695661/full
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