Correspondence Between Genomic- and Genealogical/Coalescent-Based Inference of Homozygosity by Descent in Large French-Canadian Genealogies

Research on the genetics of complex traits overwhelmingly focuses on the additive effects of genes. Yet, animal studies have shown that non-additive effects, in particular homozygosity effects, can shape complex traits. Recent investigations in human studies found some significant homozygosity effec...

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Principais autores:	Kelly M. Burkett, Mohan Rakesh, Patricia Morris, Hélène Vézina, Catherine Laprise, Ellen E. Freeman, Marie-Hélène Roy-Gagnon
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2022-01-01
Series:	Frontiers in Genetics
Assuntos:	homozygosity by descent founder populations, genealogical data coalescent models most recent common ancestor simulations
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fgene.2021.808829/full
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