USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration

Background: Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain. Programmed cell death, particularly necroptosis, contributes to nucleus pulposus (NP) cell loss. Mixed lineage kinase domain-like protein (MLKL) phosphorylation plays a critical role in necroptotic execu...

詳細記述

書誌詳細

主要な著者:	Zhenyu Zhu, Xiaofeng Lin, Fanqi Kong, Ziran Wang, Yongcheng Liang, Chenglong Ji, Hongxuan Chen, Kaiqiang Sun, Changnan Wang, Ximing Xu, Jiangang Shi
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2026-01-01
シリーズ:	Journal of Orthopaedic Translation
主題:	USP39 MLKL Deubiquitination Necroptosis Intervertebral disc degeneration
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2214031X25002001
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!