Ruxolitinib in GvHD (RIG) study: a multicenter, randomized phase 2 trial to determine the response rate of Ruxolitinib and best available treatment (BAT) versus BAT in steroid-refractory acute graft-versus-host disease (aGvHD) (NCT02396628)

Abstract Background Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause inflammation and tissue damage in GvHD target organs such as liver, gut and skin. Cytokine receptor associated kinases JAK1 and...

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Bibliografski detalji

Glavni autori:	Nikolas von Bubnoff, Gabriele Ihorst, Olga Grishina, Nadine Röthling, Hartmut Bertz, Justus Duyster, Jürgen Finke, Robert Zeiser
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2018-11-01
Serija:	BMC Cancer
Teme:	Steroid-refractory GvHD Ruxolitinib JAK inhibitor Biomarkers Inflammatory cytokines
Online pristup:	http://link.springer.com/article/10.1186/s12885-018-5045-7
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