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Palmatine Attenuates LPS-Induced EMT in MAC-T Cells and Mammary Fibrosis in Mice, with Suppression of NF-κB/TGF-β1/Smad Signaling In Vivo

Bovine mastitis is a common inflammatory disease that can progress to mammary fibrosis, thereby impairing udder health, milk yield, and milk quality. This study investigated the protective effects of palmatine on lipopolysaccharide (LPS)-induced epithelial–mesenchymal transition (EMT) in bovine mamm...

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Principais autores: Dongxue Shi, Dan Bao, Peiru Li, Kejiang Liu, Qi Wang, Weitao Dong, Xingxu Zhao, Yong Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2026-04-01
coleção:Animals
Assuntos:
palmatine
bovine mammary epithelial cells
epithelial–mesenchymal transition
mammary fibrosis
NF-κB
TGF-β1/Smad
Acesso em linha:https://www.mdpi.com/2076-2615/16/8/1187
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