Neuronal differentiation and activity drive nucleocytoplasmic shuttling of the intellectual disability kinase TLK2

IntroductionAutosomal dominant intellectual developmental disorder 57 (MRD57) is a rare neurodevelopmental disorder characterised by delayed language and psychomotor development, intellectual disability, hypotonia, gastrointestinal issues and facial dysmorphia. It is linked to genetic mutations in t...

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Hlavní autoři:	Lubna Nuhu-Soso, Heidi Denton, Darren L. Goffin, Ines Hahn, Gareth J. O. Evans
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-04-01
Edice:	Frontiers in Cellular Neuroscience
Témata:	kinase neurodevelopmental disorder neuronal differentiation nuclear localisation signal splice variant
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fncel.2026.1699735/full
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