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Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy

Ivermectin (IVM) could cause potential neurotoxicity; however, the precise molecular mechanisms remain unclear. This study explores the cytotoxicity of IVM in human neuroblastoma (SH-SY5Y) cells and the underlying molecular mechanisms. The results show that IVM treatment (2.5–15 μM) for 24 h could i...

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Autori principali: Yuan Zhang, Tun Sun, Meng Li, Yanling Lin, Yue Liu, Shusheng Tang, Chongshan Dai
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2022-05-01
Serie:Antioxidants
Soggetti:
ivermectin
neurotoxicity
oxidative stress
apoptosis
autophagy
Akt/mTOR pathway
Accesso online:https://www.mdpi.com/2076-3921/11/5/908
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