Inhibition of autophagy enhances the antitumor efficacy of T/CAR T cell against neuroblastoma

Abstract Neuroblastoma (NB) is the most common extracranial solid tumor in children characterized by poor immune infiltration and resistance to adaptive immunity, contributing to its limited response to immunotherapy. A key mechanism underlying immune evasion in cancer is autophagy, a cellular proce...

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主要な著者:	Francesca De Mitri, Manuela Giansanti, Ombretta Melaiu, Dorothee Haas, Stefan Ebert, Nicola Tumino, Elisabetta Vulpis, Francesca Gatto, Beatrice Martuscelli, Manuela Antonioli, Elisabetta Sangiuliano, Simona Caruso, Marco Scarsella, Cristiano De Stefanis, Veronica Marabitti, Silvia Campello, Doriana Fruci, Paola Vacca, Ignazio Caruana, Francesca Nazio
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2025-07-01
シリーズ:	Journal of Experimental & Clinical Cancer Research
主題:	Neuroblastoma Immune cells GD2.CAR T Chloroquine ULK1 inhibitor
オンライン･アクセス:	https://doi.org/10.1186/s13046-025-03453-0
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