APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.

Pancreatic cancer is a largely incurable disease, and increasing evidence supports strategies targeting multiple molecular mediators of critical functions of pancreatic ductal adenocarcinoma cells. Intracellular redox state modulates the activity of various signal transduction pathways and biologica...

Полное описание

Библиографические подробности

Главные авторы:	Angelo A Cardoso, Yanlin Jiang, Meihua Luo, April M Reed, Safi Shahda, Ying He, Anirban Maitra, Mark R Kelley, Melissa L Fishel
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2012-01-01
Серии:	PLoS ONE
Online-ссылка:	http://europepmc.org/articles/PMC3477158?pdf=render
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