Human metapneumovirus inhibits IFN-β signaling by downregulating Jak1 and Tyk2 cellular levels.

Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, inhibits type I interferon (IFN) signaling by an unidentified mechanism. In this study, we showed that infection of airway epithelial cells with hMPV decreased cellular level of Janus tyrosine kinase (Jak1) and...

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Библиографические подробности

Главные авторы:	Junping Ren, Deepthi Kolli, Tianshuang Liu, Renling Xu, Roberto P Garofalo, Antonella Casola, Xiaoyong Bao
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2011-01-01
Серии:	PLoS ONE
Online-ссылка:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024496&type=printable
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