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Generation and Characterization of a Zebrafish Model for <i>ADGRV1-</i>Associated Retinal Dysfunction Using CRISPR/Cas9 Genome Editing Technology

Worldwide, around 40,000 people progressively lose their eyesight as a consequence of retinitis pigmentosa (RP) caused by pathogenic variants in the <i>ADGRV1</i> gene, for which currently no treatment options exist. A model organism that mimics the human phenotype is essential to unravel the exact...

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Autores principales: Merel Stemerdink, Sanne Broekman, Theo Peters, Hannie Kremer, Erik de Vrieze, Erwin van Wijk
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2023-06-01
Colección:Cells
Materias:
<i>ADGRV1</i>
Usher syndrome
CRISPR/Cas9
zebrafish
retinal dysfunction
retinitis pigmentosa
Acceso en línea:https://www.mdpi.com/2073-4409/12/12/1598
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