Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism

Abstract Dysfunction of calcium channels is involved in the development and progression of some cancers. However, it remains unclear the role of calcium channel inhibitors in tumor immunomodulation. Here, calcium channel blocker lacidipine is identified to potently inhibit the enzymatic activity and...

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Principais autores:	Yuwen Sheng, Chong Qiao, Zhonghui Zhang, Xiaoke Shi, Linhan Yang, Ruiying Xi, Jialing Yu, Wanli Liu, Guolin Zhang, Fei Wang
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2025-01-01
Serija:	Advanced Science
Teme:	breast cancer calcium channel indoleamine 2, 3‐dioxygenase immunotherapy lacidipine
Online dostop:	https://doi.org/10.1002/advs.202409310
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