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Inhibition of eEF2 kinase ameliorates hepatic injury induced by ACR through regulation of the MAPK pathway

Background and aims: Acrylamide (ACR) induces hepatotoxicity, yet its underlying mechanisms remain incompletely understood. Our prior proteomic analysis of serum from occupationally ACR-exposed individuals identified significantly elevated levels of eukaryotic elongation factor 2 (eEF2). Given that...

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Principais autores: Zhi-Ming Li, Xiao-Li Wang, Hong-Wei Yao, Guo-Bing Yu, Xin-Yu Wang, Ru-Nan Zhang, Xiao-Xiao Hao, Wei-Wei Ma, Yu-Meng Xu, Hong-Qiu Li, Ya-Ting Lei, Fang-Fang Zhao, Cui-Ping Yu, Yong-Hui Wu, Yu-Lin Pan, Sheng-Yuan Wang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-09-01
Serier:Ecotoxicology and Environmental Safety
Fag:
Acrylamide
EEF2K
Hepatic injury
Sphingolipids
MAPK signaling pathway
Online adgang:http://www.sciencedirect.com/science/article/pii/S0147651325012436
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