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An Unbiased CRISPR-Cas9 Screening Method for the Identification of Positive and Negative Regulatory Proteins of Cell Adhesion

Mature B-cell lymphomas are highly dependent upon the protective lymphoid organ microenvironment for their growth and survival. Targeting integrin-mediated homing and retention of the malignant B cells in the lymphoid organs, using the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib, is a highly...

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Principais autores: Yvonne Thus, Martin de Rooij, Roderick Beijersbergen, Marcel Spaargaren
Formato: Artigo
Idioma:Inglês
Publicado: Bio-protocol LLC 2022-11-01
Series:Bio-Protocol
Acceso en liña:https://bio-protocol.org/en/bpdetail?id=4545&type=0
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