Persistence of CRISPR/Cas9 gene edited hematopoietic stem cells following transplantation: A systematic review and meta‐analysis of preclinical studies

Abstract Gene editing blood‐derived cells is an attractive approach to cure selected monogenic diseases but remains experimental. A systematic search of preclinical controlled studies is needed to determine the persistence of edited cells following reinfusion. All studies identified in our systemati...

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Detalhes bibliográficos

Principais autores:	Harinad B. Maganti, Adrian J. M. Bailey, Aidan M. Kirkham, Risa Shorr, Nicolas Pineault, David S. Allan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2021-07-01
coleção:	Stem Cells Translational Medicine
Assuntos:	CRISPR/Cas9 gene editing gene therapy genetic disease hematopoietic stem cells monogenic disorders
Acesso em linha:	https://doi.org/10.1002/sctm.20-0520
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