POLQ knockdown inhibits proliferation, migration, and invasion by inducing cell cycle arrest in colorectal cancer

Abstract Background Polymerase θ (POLQ) is an error-prone translesion synthesis polymerase that participates in the repair of DNA double-strand breaks. Previous studies have reported that the level of POLQ expression is distinctly upregulated in colorectal cancer (CRC), but little attention has been...

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Bibliografski detalji

Glavni autori:	Qing Yao, Shuyang Gao, Qiannan Sun, Liuhua Wang, Jun Ren, Daorong Wang
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer 2024-11-01
Serija:	Discover Oncology
Teme:	Polymerase θ Colorectal cancer Cell cycle signaling pathway DNA replication
Online pristup:	https://doi.org/10.1007/s12672-024-01496-x
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