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Human plasma proteomic profile of clonal hematopoiesis

Abstract Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer insights into downstream clinical consequences. Here we explore these patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcome...

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Principais autores: Zhi Yu, Amélie Vromman, Ngoc Quynh H. Nguyen, Art Schuermans, Linke Li, Thiago Rentz, Tetsushi Nakao, Shamsudheen K. Vellarikkal, Md Mesbah Uddin, Abhishek Niroula, Gabriel Griffin, Michael C. Honigberg, Amy E. Lin, Christopher J. Gibson, Daniel H. Katz, Usman A. Tahir, Shi Fang, Jacqueline S. Dron, Michael Pan, Sara Haidermota, Shriienidhie Ganesh, Tajmara Antoine, Joshua Weinstock, Thomas R. Austin, Ramachandran S. Vasan, Gina M. Peloso, Whitney Hornsby, Peter Ganz, JoAnn E. Manson, Bernhard Haring, Charles Kooperberg, Alexander P. Reiner, Joshua C. Bis, Bruce M. Psaty, Yuan-I Min, Adolfo Correa, Leslie A. Lange, Wendy S. Post, Jerome I. Rotter, Stephen S. Rich, James G. Wilson, Benjamin L. Ebert, Bing Yu, Christie M. Ballantyne, Josef Coresh, Vijay G. Sankaran, Alexander G. Bick, Siddhartha Jaiswal, Robert E. Gerszten, NHLBI Trans-Omics for Precision Medicine, Peter Libby, Rajat M. Gupta, Pradeep Natarajan
Format: Artigo
Jezik:Inglês
Izdano: Nature Portfolio 2025-11-01
Serija:Nature Communications
Online dostop:https://doi.org/10.1038/s41467-025-66755-z
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