PIK75 effectively reverses PI3K‒AKT activation caused by palbociclib resistance and synergistically inhibits the progression of esophageal squamous cell carcinoma

Abstract China is one of the countries with a high incidence of esophageal squamous cell carcinoma (ESCC). At present, the main treatment method for ESCC is surgery combined with chemotherapy and radiotherapy, and the efficacy of drug therapy is not ideal. Cyclin-dependent kinase inhibitors (CDKi) h...

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Автори:	Yaning Zhao, Luxi Li, Yu Jiang, Yujiao Sun, Yi Xu, Xinyi Ye, Fangming Zhang, Fenxia Zhu, Yunzhi Pan, Sai Ma
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Nature Portfolio 2025-11-01
Серія:	Scientific Reports
Предмети:	Esophageal squamous cell carcinoma (ESCC) Cell cycle Palbociclib PI3K‒AKT pathway PIK75
Онлайн доступ:	https://doi.org/10.1038/s41598-025-26858-5
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