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Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine

Abstract Malaria, caused by Plasmodium parasites, remains one of the most devastating infectious diseases worldwide, despite control efforts to lower morbidity and mortality. Both advanced candidate vaccines, RTS,S and R21, are subunit (SU) vaccines that target a single Plasmodium falciparum (Pf) pr...

Ausführliche Beschreibung

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Hauptverfasser: Zachary MacMillen, Kiara Hatzakis, Adrian Simpson, Melanie J. Shears, Felicia Watson, Jesse H. Erasmus, Amit P. Khandhar, Brandon Wilder, Sean C. Murphy, Steven G. Reed, James W. Davie, Marion Avril
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2024-01-01
Schriftenreihe:npj Vaccines
Online-Zugang:https://doi.org/10.1038/s41541-023-00799-4
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