Context-specific targeting of focal adhesion kinase in brain tumors: lessons from glioblastoma and neurofibromatosis type 2-mutant meningioma

Focal adhesion kinase (FAK) has long been explored as a therapeutic target in glioblastoma (GBM) based on its overexpression and involvement in invasive signaling. However, clinical trials have consistently failed to show benefit - highlighting a core principle of translational oncology: target pres...

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Bibliografische Detailangaben

Hauptverfasser:	Andre Sagerer, Ilker Y. Eyüpoglu, Tareq A. Juratli, Nils Cordes
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-12-01
Schriftenreihe:	Frontiers in Oncology
Schlagworte:	FAK inhibitor focal adhesion kinase glioblastoma NF2-mutant meningioma pFAK-Y397 precision oncology
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1724278/full
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