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Momordica charantia L.-derived exosome-like nanovesicles stabilize p62 expression to ameliorate doxorubicin cardiotoxicity

Abstract Background Doxorubicin (DOX) is a first-line chemotherapeutic drug for various malignancies that causes cardiotoxicity. Plant-derived exosome-like nanovesicles (P-ELNs) are growing as novel therapeutic agents. Here, we investigated the protective effects in DOX cardiotoxicity of ELNs from M...

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Principais autores: Cong Ye, Chen Yan, Si-Jia Bian, Xin-Ran Li, Yu Li, Kai-Xuan Wang, Yu-Hua Zhu, Liang Wang, Ying-Chao Wang, Yi-Yuan Wang, Tao-Sheng Li, Su-Hua Qi, Lan Luo
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2024-08-01
Series:Journal of Nanobiotechnology
Assuntos:
Momordica charantia L.-derived exosome-like nanovesicles
Doxorubicin cardiotoxicity
p62/Keap1
Ubiquitination
Nrf2
Acceso en liña:https://doi.org/10.1186/s12951-024-02705-z
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