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Histone lysine crotonylation accelerates ACSL4-mediated ferroptosis of keratinocytes via modulating autophagy in diabetic wound healing

Dysfunction of keratinocytes affects diabetic wound healing, but underlying mechanisms have not been understood. This study examines crotonylation's role in ferroptosis and autophagy in keratinocytes, particularly regarding ACSL4, using STZ-induced diabetic rats and high glucose-exposed keratinocyte...

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Principais autores: Fengjuan Li, Haowen Ye, Lanlan Li, Qingling Chen, Xianwu Lan, Liangxiu Wu, Bin Li, Lishan Li, Chuxian Guo, Milad Ashrafizadeh, Gautam Sethi, Jun Guo, Liangyan Wu
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-03-01
Serier:Pharmacological Research
Fag:
Crotonylation
Autophagy
Ferroptosis
ACSL4
Diabetic wound healing
Online adgang:http://www.sciencedirect.com/science/article/pii/S104366182500057X
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