Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation

Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the FDA for the oral treatment of premenopausal women with hypoactive sexual desire disorder. FLB is a centrally acting drug that has a low oral bioavailability of 33% owing to its exposure to the hepatic first-p...

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Bibliografische Detailangaben

Hauptverfasser:	Usama A. Fahmy, Shaimaa M. Badr-Eldin, Osama A. A. Ahmed, Hibah M. Aldawsari, Singkome Tima, Hani Z. Asfour, Mohammed W. Al-Rabia, Aya A. Negm, Muhammad H. Sultan, Osama A. A. Madkhali, Nabil A. Alhakamy
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-05-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	flibanserin niosomes Span<sup>®</sup> 85 cholesterol gellan gum ex vivo permeation
Online-Zugang:	https://www.mdpi.com/1999-4923/12/6/485
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