Serine/threonine kinase 33 mediates thrombin-induced interleukin-8 release from human lung epithelial cells in severe asthma

Abstract Interleukin (IL)-8, also known as chemokine (CXC motif) ligand 8, contributes to the pathogenesis of neutrophilic asthma. Thrombin exacerbates IL-8/CXCL8-mediated inflammatory responses. However, the underlying mechanisms remain unclear. Phosphorylation of serine/threonine kinase 33 (STK33)...

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Auteurs principaux:	Wun-Hao Cheng, Wen-Shan Chang, Po-Hao Feng, Kuan-Yuan Chen, Kang-Yun Lee, Yu-Chih Wu, Lee-Yuan Lin, Fara Silvia Yuliani, Chien-Huang Lin, Bing-Chang Chen
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-10-01
Collection:	Respiratory Research
Sujets:	Severe asthma STK33 Thrombin IL-8/CXCL8 C-Myc Epithelial cell
Accès en ligne:	https://doi.org/10.1186/s12931-025-03368-6
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