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Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen

Abstract Background Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from treatment with hypomethylating agents (HMAs), but no predictive biomarkers...

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Autors principals: Maximilian Schmutz, Manuela Zucknick, Richard F. Schlenk, Daniel Mertens, Axel Benner, Dieter Weichenhan, Oliver Mücke, Konstanze Döhner, Christoph Plass, Lars Bullinger, Rainer Claus
Format: Artigo
Idioma:Inglês
Publicat: BMC 2023-10-01
Col·lecció:Clinical Epigenetics
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Accés en línia:https://doi.org/10.1186/s13148-023-01580-z
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