TCF4 trinucleotide repeat expansion drives distinct proteomic signatures in Fuchs endothelial corneal dystrophy

Abstract The aims of this study were to use an isogenic cell model system to investigate the proteomic consequences of TCF4 trinucleotide repeat expansion in Fuchs endothelial corneal dystrophy (FECD) and to identify potential molecular pathways contributing to disease pathogenesis. We used our prev...

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Dettagli Bibliografici

Autori principali:	Taichi Yuasa, Tatsuya Nakagawa, Tetsuro Honda, Go Nishiuchi, Masakazu Sato, Ayumi Tokunaga, Makiko Nakahara, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Prema Padmanabhan, Amit Chatterjee, Gajanan Sathe, Vivek Ghose, Narayanan Janakiraman, Noriko Koizumi, Sailaja V. Elchuri, Naoki Okumura
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-03-01
Serie:	Scientific Reports
Accesso online:	https://doi.org/10.1038/s41598-026-43789-x
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