Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance

Background & Aims: Lipotoxicity triggers non-alcoholic fatty liver disease (NAFLD) progression owing to the accumulation of toxic lipids in hepatocytes including saturated fatty acids (SFAs), which activate pro-inflammatory pathways. We investigated the impact of hepatocyte- or circulating-deriv...

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Ngā kaituhi matua:	Irma Garcia-Martinez, Rosa Alen, Laura Pereira, Adrián Povo-Retana, Alma M. Astudillo, Ana B. Hitos, Isabel Gomez-Hurtado, Eduardo Lopez-Collazo, Lisardo Boscá, Rubén Francés, Ignacio Lizasoain, María Ángeles Moro, Jesús Balsinde, Manuel Izquierdo, Ángela M. Valverde
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2023-08-01
Rangatū:	JHEP Reports
Ngā marau:	NAFLD Lipotoxicity Inflammation Insulin resistance Extracellular vesicles TLR4
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2589555923000873
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!