Mitochondrial DNA release via mPTP and BAX/BAK drives inflammatory injury in intestinal ischemia reperfusion

Abstract Background Intestinal ischemia reperfusion (IIR) is a challenging and life-threatening clinical condition, with disease progression closely linked to excessive inflammatory responses. As a potent activator of innate immunity, the mechanism underlying mitochondrial DNA (mtDNA) release across...

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Detalhes bibliográficos

Principais autores:	Yixin Jing, Yiguo Zhang, Tulanisa Kadier, Ke Ding, Rong Chen, Qingtao Meng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-12-01
coleção:	Cell Communication and Signaling
Assuntos:	IIR mtDNA MCU mPTP BAX/BAK
Acesso em linha:	https://doi.org/10.1186/s12964-025-02603-3
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