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A Treg-Selective IL-2 Mutein Prevents the Formation of Factor VIII Inhibitors in Hemophilia Mice Treated With Factor VIII Gene Therapy

Hemophilia A is a genetic disorder that results in the deficiency of functional factor VIII protein, which plays a key role in blood coagulation. Currently, the majority of hemophilia A patients are treated with repeated infusions of factor VIII protein. Approximately 30% of severe hemophilia A pati...

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Hoofdauteurs: Alex C. Chen, Xiaohe Cai, Chong Li, Liliane Khoryati, Marc A. Gavin, Carol H. Miao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020-04-01
Reeks:Frontiers in Immunology
Onderwerpen:
IL-2
hemophilia
factor VIII
inhibitors
Tregs
tolerance
Online toegang:https://www.frontiersin.org/article/10.3389/fimmu.2020.00638/full
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