Identification of Specific Trafficking Defects of Naturally Occurring Variants of the Human ABCG2 Transporter
Proper targeting of the urate and xenobiotic transporter ATP-binding transporter subfamily G member 2 (ABCG2) to the plasma membrane (PM) is essential for its normal function. The naturally occurring Q141K and M71V polymorphisms in ABCG2, associated with gout and hyperuricemia, affect the cellular r...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2021-02-01
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| Serie: | Frontiers in Cell and Developmental Biology |
| Soggetti: | |
| Accesso online: | https://www.frontiersin.org/articles/10.3389/fcell.2021.615729/full |
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