The Potent Trypanocidal Effect of LQB303, a Novel Redox-Active Phenyl-Tert-Butyl-Nitrone Derivate That Causes Mitochondrial Collapse in Trypanosoma cruzi

Chagas disease, which is caused by Trypanosoma cruzi, establishes lifelong infections in humans and other mammals that lead to severe cardiac and gastrointestinal complications despite the competent immune response of the hosts. Furthermore, it is a neglected disease that affects 8 million people wo...

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Autors principals:	Carolina Machado Macedo, Francis Monique de Souza Saraiva, Jéssica Isis Oliveira Paula, Suelen de Brito Nascimento, Débora de Souza dos Santos Costa, Paulo Roberto Ribeiro Costa, Ayres Guimarães Dias, Marcia Cristina Paes, Natália Pereira Nogueira
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-04-01
Col·lecció:	Frontiers in Microbiology
Matèries:	Trypanosoma cruzi chemotherapy bioenergetics high-resolution respirometry mitochondrion tropical neglected disease
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fmicb.2021.617504/full
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