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Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies

The 15-amino-acid primary immunodominant (PID) region on HIV-1 gp41 adopts an ensemble of conformational states. This conformational plasticity is suggested to misdirect the early humoral immune response.

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Bibliografische Detailangaben
Hauptverfasser: Jonathan D. Cook, Adree Khondker, Jeffrey E. Lee
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2022-03-01
Schriftenreihe:Communications Biology
Online-Zugang:https://doi.org/10.1038/s42003-022-03235-w
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