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Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2

Abstract Acute kidney injury (AKI) has become a disease of global concern due to its high morbidity and mortality. This has highlighted the need for renoprotective agents. Astragaloside IV (AS-IV) is a saponin isolated from Astragalus membranaceus with good antioxidant, anti-inflammatory and anti-tu...

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Principais autores: Yuchen Li, Jiayi Zhou, Tianxin Zhang, Xiaocong Li, Cheng Wu, Ziyi Zhao, Jianyuan Tang, Xiaoyu Tan, Qiongying Hu, Wenhao Liao
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-01-01
Serier:Scientific Reports
Fag:
Acute kidney injury
Astragaloside IV
Heavy metal cadmium
Oxidative stress
Apoptosis
Online adgang:https://doi.org/10.1038/s41598-025-86312-4
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