Pain signaling via sensory neurons drives breast cancer progression through neuropeptide release and κ-opioid counter-regulation

Severe pain in patients with breast cancer is associated with poorer survival outcomes, yet the mechanisms linking nociceptive signaling to tumor progression remain unclear. In a clinical cohort, breast cancer patients whose moderate or severe pain improved under specialized palliative care exhibite...

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Autori principali:	Hitoshi Makabe, Michiko Narita, Yasuyuki Nagumo, Masanori Fujiwara, Yusuke Hamada, Jion Takise, Takumi Yoshizawa, Sakura Sano, Shin Iizuka, Eri Asaba, Yukari Suda, Tomohisa Mori, Tsuyoshi Saitoh, Hiroshi Nagase, Vivianne L. Tawfik, Shigehiro Yagishita, Akinobu Hamada, Kan Yonemori, Shin Takayama, Masayuki Yoshida, Ryo Yoshizawa, Kenichi G.N. Suzuki, Rinshi S. Kasai, Naoko Kuzumaki, Eriko Satomi, Minoru Narita
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-03-01
Serie:	Pharmacological Research
Soggetti:	Breast cancer Sensory neuron CGRP Dynorphin Substance P Induced pluripotent stem cell (iPSC)
Accesso online:	http://www.sciencedirect.com/science/article/pii/S1043661826000289
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