SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNA

The on-going global pandemic of COVID-19 is caused by SARS-CoV-2, which features a proofreading mechanism to facilitate the replication of its large RNA genome. The 3′-to-5′ exoribonuclease (ExoN) activity of SARS-CoV-2 non-structural protein 14 (nsp14) removes nucleotides misincorporated during RNA...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Nicholas H. Moeller, Kellan T. Passow, Daniel A. Harki, Hideki Aihara
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-08-01
coleção:	Viruses
Assuntos:	SARS-CoV-2 nsp14 proofreading chain terminator ddhCTP RNA-dependent RNA polymerase
Acesso em linha:	https://www.mdpi.com/1999-4915/14/8/1790
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!