IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B cells. Because these isotypes are presumed to be redundant, it is unknown how this could impose tolerance. We introduced th...

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Detalhes bibliográficos

Principais autores:	Mark Noviski, James L Mueller, Anne Satterthwaite, Lee Ann Garrett-Sinha, Frank Brombacher, Julie Zikherman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2018-03-01
coleção:	eLife
Assuntos:	B cell receptor IgM IgD autoimmune response/disease signal transduction antibody responses
Acesso em linha:	https://elifesciences.org/articles/35074
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