p40phox-Deficient Mice Exhibit Impaired Bacterial Clearance and Enhanced Pro-inflammatory Responses during Salmonella enterica serovar Typhimurium Infection

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a major cause of acute gastroenteritis in humans. During infection, reactive oxygen species (ROS), generated from NADPH oxidase (a multisubunit enzyme complex), are required for pathogen killing upon phagocytosis and for regulating pro-infl...

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Autores principales:	Yali Li, Meili Lv, Chienwen Su, Shaorong Long, Wei Zhang, Kara L. Conway, Weifen Li, Ramnik J. Xavier, Hai Ning Shi
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2017-10-01
Colección:	Frontiers in Immunology
Materias:	NADPH oxidase bacterial killing mucosa inflammation Salmonella infection
Acceso en línea:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01270/full
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