Mind the Gap—Deciphering GPCR Pharmacology Using 3D Pharmacophores and Artificial Intelligence

G protein-coupled receptors (GPCRs) are amongst the most pharmaceutically relevant and well-studied protein targets, yet unanswered questions in the field leave significant gaps in our understanding of their nuanced structure and function. Three-dimensional pharmacophore models are powerful computat...

Полное описание

Библиографические подробности

Главные авторы:	Theresa Noonan, Katrin Denzinger, Valerij Talagayev, Yu Chen, Kristina Puls, Clemens Alexander Wolf, Sijie Liu, Trung Ngoc Nguyen, Gerhard Wolber
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2022-10-01
Серии:	Pharmaceuticals
Предметы:	ligand-based pharmacophores structure-based pharmacophores virtual screening drug design machine learning molecular dynamics
Online-ссылка:	https://www.mdpi.com/1424-8247/15/11/1304
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!