Three tyrosine kinase inhibitors cause cardiotoxicity by inducing endoplasmic reticulum stress and inflammation in cardiomyocytes

Abstract Background Tyrosine kinase inhibitors (TKIs) are anti-cancer therapeutics often prescribed for long-term treatment. Many of these treatments cause cardiotoxicity with limited cure. We aim to clarify molecular mechanisms of TKI-induced cardiotoxicity so as to find potential targets for treat...

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Detalhes bibliográficos

Principais autores:	Huan Wang, Yiming Wang, Jiongyuan Li, Ziyi He, Sarah A. Boswell, Mirra Chung, Fuping You, Sen Han
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-04-01
coleção:	BMC Medicine
Assuntos:	Cardiotoxicity Tyrosine kinase inhibitor Transcriptomics Endoplasmic reticulum stress Inflammation
Acesso em linha:	https://doi.org/10.1186/s12916-023-02838-2
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