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Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition

Abstract Background Activated Cdk5 regulates a number of processes during nervous system formation, including neuronal differentiation, growth cone stabilization, and axonal growth. Cdk5 phosphorylates its downstream substrates located in axonal growth cones, where the highly expressed c-Jun N-termi...

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Principais autores: Doo Soon Im, Alvin Joselin, Devon Svoboda, Tesuya Takano, Maxime W. C. Rousseaux, Steve Callaghan, Ruth S. Slack, Shin-ichi Hisanaga, Roger J. Davis, David S. Park, Dianbo Qu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-05-01
coleção:BMC Biology
Assuntos:
Axonal outgrowth
Cdk5
Itch
JIP1
Notch1
phosphorylation
Acesso em linha:https://doi.org/10.1186/s12915-022-01312-4
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