Cure of ADPKD by selection for spontaneous genetic repair events in Pkd1-mutated iPS cells.
Induced pluripotent stem cells (iPSCs) generated by epigenetic reprogramming of personal somatic cells have limited therapeutic capacity for patients suffering from genetic disorders. Here we demonstrate restoration of a genomic mutation heterozygous for Pkd1 (polycystic kidney disease 1) deletion (...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2012-01-01
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| Serie: | PLoS ONE |
| Accesso online: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032018&type=printable |
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