Enterovirus A71 3AB protein facilitates immune evasion by blocking cGAS recognition of mtDNA

Abstract Mitochondrial DNA (mtDNA) is a powerful stimulator of the innate immune system and has been shown to trigger cytosolic DNA-sensing signaling during picornavirus infection. In this study, we observe that EV-A71 infection induces mitochondrial damage and leads to the release of mtDNA into the...

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Hlavní autoři:	Peng Sun, Xinya Yang, Jing Cui, Guicun Fang, Yuqin Wu, Jingyi Chang, Xiaofei Li, Yinli Xie, Lipeng Gan, Lina Ma, Zhiyong Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2026-04-01
Edice:	EMBO Reports
Témata:	cGAS EV-A71 Immune Evasion mtDNA Phase Separation
On-line přístup:	https://doi.org/10.1038/s44319-026-00756-x
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