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An Abscopal Effect on Lung Metastases in Canine Mammary Cancer Patients Induced by Neoadjuvant Intratumoral Immunotherapy with Cowpea Mosaic Virus Nanoparticles and Anti-Canine PD-1

Neoadjuvant intratumoral (IT) therapy could amplify the weak responses to checkpoint blockade therapy observed in breast cancer (BC). In this study, we administered neoadjuvant IT anti-canine PD-1 therapy (IT acPD-1) alone or combined with IT cowpea mosaic virus therapy (IT CPMV/acPD-1) to companion...

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Main Authors: Petra Sergent, Juan Carlos Pinto-Cárdenas, Adhara Jaciel Arreguin Carrillo, Daniel Luna Dávalos, Marisa Daniela González Pérez, Dora Alicia Mendoza Lechuga, Daniel Alonso-Miguel, Evelien Schaafsma, Abigail Jiménez Cuarenta, Diana Cárdenas Muñoz, Yuliana Zarabanda, Scott M. Palisoul, Petra J. Lewis, Fred W. Kolling, Jessica Fernanda Affonso de Oliveira, Nicole F. Steinmetz, Jay L. Rothstein, Louise Lines, Randolph J. Noelle, Steven Fiering, Hugo Arias-Pulido
Format: Artigo
Language:Inglês
Published: MDPI AG 2024-09-01
Series:Cells
Subjects:
canine mammary carcinomas
intratumoral injections
plant virus
cowpea mosaic virus
immune cells
tumor microenvironment
Online Access:https://www.mdpi.com/2073-4409/13/17/1478
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