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Electrophilic Aldehyde 4-Hydroxy-2-Nonenal Mediated Signaling and Mitochondrial Dysfunction

Reactive oxygen species (ROS), a by-product of aerobic life, are highly reactive molecules with unpaired electrons. The excess of ROS leads to oxidative stress, instigating the peroxidation of polyunsaturated fatty acids (PUFA) in the lipid membrane through a free radical chain reaction and the form...

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Principais autores: Sudha Sharma, Papori Sharma, Tara Bailey, Susmita Bhattarai, Utsab Subedi, Chloe Miller, Hosne Ara, Srivatsan Kidambi, Hong Sun, Manikandan Panchatcharam, Sumitra Miriyala
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-10-01
coleção:Biomolecules
Assuntos:
oxidative stress
lipid peroxidation
4-hydroxynonenal
mitochondrial dysfunction
Acesso em linha:https://www.mdpi.com/2218-273X/12/11/1555
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