RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21

Abstract Background Prior evidence demonstrated that Regulator of G protein Signaling 6 (RGS6) translocates to the nucleolus in response to cytotoxic stress though the functional significance of this phenomenon remains unknown. Methods Utilizing in vivo gene manipulations in mice, primary murine car...

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Principais autores:	Abhishek Singh Sengar, Manish Kumar, Chetna Rai, Sreemoyee Chakraborti, Dinesh Kumar, Pranesh Kumar, Sukhes Mukherjee, Kausik Mondal, Adele Stewart, Biswanath Maity
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2024-02-01
Serija:	Journal of Translational Medicine
Teme:	Cardiotoxicity G-protein RGS proteins Chemotherapy Nucleolar stress
Online dostop:	https://doi.org/10.1186/s12967-024-04985-3
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