Ergothioneine rescues obesity-induced testicular dysfunction via dual restoration of steroidogenesis and mitochondrial redox homeostasis

Background: Although obesity is closely linked to reduced male fertility, the specific testicular metabolic and redox mechanisms driving impaired spermatogenesis remain elusive. Methods: Using a high-fat diet (HFD) mouse model, combined with multi-omics profiling, cellular assays, and ex vivo human...

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Autori principali:	Xiaomin Li, Jiajing Lin, Man Wu, Feixue Han, Shuyan Chen, Hongfei Ke, Zhiying Huang, Tianwen Peng, Yu Lan, Xin Fu, You Che, Zhicong Chen, Geng An
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-04-01
Serie:	Redox Biology
Soggetti:	Ergothioneine Obesity-induced testicular dysfunction Oxidative stress Steroidogenesis Mitochondrial redox balance
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2213231726000881
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