Impact of beta-lactam antibiotic renal dose adjustment on clinical outcomes in patients with septic shock and acute kidney injury from gram-negative bloodstream infections: a multicenter observational study

Objective: Beta-lactam antibiotics are the backbone of therapy for critically ill patients with sepsis; however, these patients experience pharmacokinetic changes that alter beta-lactam exposure. Adjusting doses for acute kidney injury during the first 48 h of admission to the ICU, in the absence of...

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Bibliografiske detaljer

Principais autores:	Melissa L. Thompson Bastin, Megan A Rech, Kevin D. Betthauser, Mojdeh S. Heavner, Michelle Horng, Steven M. Lemieux, Mollie Lumpkin, Erin K. McCreary, Michael A. Ruggero, Patrick M. Wieruszewski, Y. Vivian Tsai, Jose Barro, Bhavna Jois, James Mease, Carly Cheng, Emily L. Heil
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2025-09-01
Serier:	CMI Communications
Fag:	Cefepime Meropenem Piperacillin/tazobactam Renal dosing Sepsis Beta-lactam
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2950590925000253
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